{"id":8338,"date":"2026-06-02T13:50:53","date_gmt":"2026-06-02T13:50:53","guid":{"rendered":"https:\/\/www.viamedsalud.com\/ivoqa\/nips-normothermic-intraperitoneal-chemotherapy\/"},"modified":"2026-06-09T10:31:54","modified_gmt":"2026-06-09T10:31:54","slug":"nips-normothermic-intraperitoneal-chemotherapy","status":"publish","type":"page","link":"https:\/\/www.viamedsalud.com\/ivoqa\/en\/nips-normothermic-intraperitoneal-chemotherapy\/","title":{"rendered":"NIPS: Normothermic Intraperitoneal Chemotherapy"},"content":{"rendered":"\t\t
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VIAMED INSTITUTE OF ADVANCED SURGICAL ONCOLOGY<\/span>

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NIPS: Normothermic Intraperitoneal Chemotherapy<\/p>\n<\/h1><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Normothermic Intraperitoneal Chemotherapy, commonly known as NIPEC<\/strong> or NIPS<\/strong> (Normothermic Intraperitoneal Chemotherapy<\/em>), represents an advanced pillar in the treatment of peritoneal carcinomatosis. This technique involves administering cytostatic drugs at body temperature (37\u00b0C)<\/strong> directly into the abdominal cavity via a catheter implanted in the abdomen, similar to the ports used for intravenous chemotherapy.<\/p>\n

Unlike other single-dose procedures, NIPS is designed for prolonged and repeated treatments<\/strong>, allowing sustained contact between the drug and the tumor cells. This is exceptionally valuable for patients who require ongoing control of microscopic disease or as a conversion therapy prior to major surgery. In fact, in Japan, some patients receive NIPS treatment continuously for years.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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What Does NIPS Treatment Involve?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The NIPEC procedure is based on the physiological principle of the blood-peritoneum barrier. This barrier allows for much higher doses of chemotherapy to be applied inside the abdomen than could ever be tolerated intravenously, as the drug barely passes into the bloodstream. Consequently, systemic side effects are reduced while the therapy acts directly on the peritoneal metastases.<\/p>\n

Unlike HIPEC, which is performed during surgery under general anesthesia, NIPS is typically administered as follows:<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Catheter Access<\/h3>

A peritoneal access device (similar to an abdominal port-a-cath) is placed either through a minimally invasive procedure performed under sedation by interventional radiologists or in the operating room via laparoscopy by surgical oncologists. This catheter remains hidden beneath the skin of the abdomen. <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Body Temperature Administration<\/h3>

The drug is infused at normal body temperature without applying heat, eliminating thermal stress on the tissues. It is carried out in the day hospital while the patient is awake\u2014much like standard intravenous chemotherapy\u2014making it comfortable and very well tolerated. <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Cyclic Treatment<\/h3>

The patient receives multiple scheduled sessions (cycles), allowing the chemotherapy to target tumor cells at different stages of their growth cycle. Typically, intraperitoneal chemotherapy is administered one day a week for three consecutive weeks each month, followed by a rest week. <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Bidirectional Chemotherapy<\/h3>

By protocol, it is most commonly combined with conventional intravenous chemotherapy. This attacks the tumor from two fronts simultaneously to maximize efficacy.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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What Differentiates NIPS from HIPEC and PIPAC?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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It is common for patients to wonder which technique is most appropriate for their case. While all three act on the peritoneum, their objectives and methods differ significantly:<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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